Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies

نویسندگان

  • Xiaofeng Jia
  • Mario I Romero-Ortega
  • Yang D Teng
چکیده

1 Department of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, Medical School Teaching Facility 559 A, Baltimore, MD 21201, USA 2Department of Biomedical Engineering, Physical Medicine & Rehabilitation, Anesthesiology & Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA 3Department of Bioengineering, The University of Texas at Dallas, Richardson, TX, USA 4 Surgery Department, University of Texas Southwestern Medical Center, TX, USA 5Departments of Neurosurgery and Physical Medicine & Rehabilitation, Harvard Medical School, Brigham and Women’s Hospital, Spaulding Rehabilitation Hospital and VA Boston Healthcare System, Boston, MA, USA

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

O6: Protective Effect of Alpha-Lipoic Acid on Neuronal Degeneration Due to Sciatic Nerve Transection in Rat

Peripheral nerve injury induces inflammation and oxidative stress, which are the most significant causes of the neuronal death. Alpha Lipoic acid (ɑ-LA) as a potent antioxidant and anti-inflammatory agent may counteract the oxidative stress and inflammatory response. This study was designed to investigate the protective effect of ɑ-LA on neuronal cell death in L4 dorsal root ganglion (L4-DRG) i...

متن کامل

Augmenting Peripheral Nerve Regeneration Using Rat Hair Follicle Stem Cells (rHFSCs) in Rats

Introduction: Nowadays, cell therapy is the most advanced treatment of peripheral nerve injury. The aim of this study was to determine the effects of transplantation of hair follicle stem cells on the regeneration of the sciatic nerve injury in rats. Methods: The bulge region of the rat whisker was isolated and cultured. Morphological and biological features of the cultured bulge cells were ob...

متن کامل

Nanotechnology for peripheral nerve regeneration

Peripheral nerve injuries (PNI) can lead to lifetime loss of function and disfigurement. Different methods such as conventional allograft procedures and using of biological tubes have problems for damaged peripheral nerves reconstruction. Designed scaffolds with natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and non-absorb...

متن کامل

Introduction of a New Suture Method in Repair of Peripheral Nerves Injured with a Sharp Mechanism

  Background: The standard method for repair of an injured peripheal nerve is epineural repair with separate sutures. Herein we describe a method in which the nerve is sutured with continous sutures. In fact this method has not been utilized for nerve repair previously and our purpose was to compare it to the standard method. If it proved to be successful it would replace the standard method in...

متن کامل

Preparation of acellular sciatic nerve scaffold and it’s mechanical and histological properties for use in peripheral nerve regeneration

Background: Tissue engineering is a developing multidisciplinary and interdisciplinary field involving the use of bioartificial implants for tissue remodeling with the target for repair and enhancing tissue or organ function. Acellular nerve has been used in experimental models as a peripheral nerve substitute. The purpose of the present study was to evaluate the mechanical and histological cha...

متن کامل

P49: The Evaluation of Aqueous Extract of Glycyrrhiza Glabra on Nerve Recovery in the Rat after Sciatic Nerve Injury

Peripheral nerve injury requires a long recovery period, and recovery, once attained, usually is incomplete. Inflammatory procedures may inhibit functional recovery after nerve injury and produce cell death in both the central nervous system and the peripheral nervous system. Since the glycyrrhiza glabra extract has anti-inflammatory effects, it could reduce the severity of injury. The aim of t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 2014  شماره 

صفحات  -

تاریخ انتشار 2014